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CMUThink Boston: New Breakthroughs in Biomedical Research: Home

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Artificial lungs to provide permanent, home-based respiratory support


Keith Cook

Professor of Biomedical Engineering, College of Engineering

Bioengineered Organs Initiative

McGowan Institute for Regenerative Medicine


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Demarest, Caitlin T., "Prolonging the Useful Lifetime of Artificial Lungs" (2017). Dissertations. 870.

Topic-related scholarly articles

Skoog, D. J., Pohlmann, J. R., Demos, D. S., Scipione, C. N., Iyengar, A., Schewe, R. E., … Cook, K. E. (2017). Fourteen Day in Vivo Testing of a Compliant Thoracic Artificial Lung. ASAIO Journal, 63(5), 644–649. Abstract available 

Thompson, A. J., Marks, L. H., Goudie, M. J., Rojas-Pena, A., Handa, H., & Potkay, J. A. (2017). A small-scale, rolled-membrane microfluidic artificial lung designed towards future large area manufacturing. Biomicrofluidics, 11(2). Abstract available.  


Neurons that can be turned on and off to alleviate the movement-related symptoms of Parkinson’s disease

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Aryn Gittis

Associate Professor of Biological Sciences, Mellon College of Science


Center for the Neural Basis of Cognition (CNBC)


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Topic-related scholarly articles

Mastro KJ, Zitelli KT, Willard AM, Leblanc KH, Kravitz AV, Gittis AH. Cell-Specific Pallidal Intervention Induces Long-Lasting Motor Recovery in Dopamine Depleted Mice. Nature neuroscience. 2017;20(6):815-823. doi:10.1038/nn.4559. Available for free on PubMed Central.

Hegeman DJ, Hong ES, Hernández VM, Chan CS. The External Globus Pallidus: Progress and Perspectives. The European journal of neuroscience. 2016;43(10):1239-1265. doi:10.1111/ejn.13196. Available for free on PubMed Central.

Mastro KJ, Bouchard RS, Holt HAK, Gittis AH. Transgenic Mouse Lines Subdivide External Segment of the Globus Pallidus (GPe) Neurons and Reveal Distinct GPe Output Pathways. The Journal of Neuroscience. 2014;34(6):2087-2099. doi:10.1523/JNEUROSCI.4646-13.2014. Available for free on PubMed Central.

Gittis AH, Berke JD, Bevan MD, et al. New Roles for the External Globus Pallidus in Basal Ganglia Circuits and Behavior. The Journal of Neuroscience. 2014;34(46):15178-15183. doi:10.1523/JNEUROSCI.3252-14.2014. Available for free on PubMed Central.

Kravitz AV, Freeze BS, Parker PRL, et al. Regulation of parkinsonian motor behaviors by optogenetic control of basal ganglia circuitry. Nature. 2010;466(7306):622-626. doi:10.1038/nature09159. Available for free on PubMed Central.